Facts about Albino Dobermans

Dr. D.F. Patterson

(updated 6/2/04)

Here are some of the papers which Dr. Patterson has authored or co-authored, listed here to help demonstrate his extensive expertise in the field of veterinary genetics and heritable diseases:

Buchanan JW, Patterson DF. (2003). Etiology of patent ductus arteriosus in dogs. J Vet Intern Med, Mar-Apr;17(2):167-71.

Casal, M. L., Giger, U., Bovee, K. C., & Patterson, D. F. (1995). Inheritance of cystinuria and renal defect in Newfoundlands. Journal of the American Veterinary Medical Association, 207(12), 1585-1589. Family studies, breeding experiments, and renal clearance studies were performed in Newfoundland dogs with cystinuria, an inherited defect in renal tubular transport of cystine and dibasic amino acids.....

Casal, M. L., Jezyk, P. F., Greek, J. M., Goldschmidt, M. H., & Patterson, D. F. (1997). X-linked ectodermal dysplasia in the dog. Journal of Heredity, 88(6), 513-517. A male German shepherd pup had symmetrical areas of hairlessness as well as missing and misshapen teeth. There was no family history of a similar phenotype. In biopsies of the hairless skin and foot pads there were no hair follicles, adnexal structures, or eccrine glands. These findings resemble those in ectodermal dysplasia in the Tabby mouse and anhidrotic/hypohidrotic ectodermal dysplasia (HED) in man, which are both X-linked recessive disorders and thought to be homologous gene defects. While similar cases of ectodermal dysplasia have been reported in the dog and some genetic studies carried out, definitive confirmation of X-linked inheritance of canine ectodermal dysplasia is lacking. Family studies and experimental matings using the propositus gave results that confirm X-linked recessive inheritance. On statistical grounds, it is concluded that ED in the propositus is due to a new mutation. A colony of dogs with this mutation is maintained for further study.

Chieffo, C., Stalis, I. H., Van Winkle, T. J., Haskins, M. E., & Patterson, D. F. (1994). Cerebellar Purkinje's cell degeneration and coat color dilution in a family of Rhodesian Ridgeback dogs. J Vet Intern Med, 8(2), 112-6. A syndrome of cerebellar Purkinje's cell degeneration and coat color dilution was diagnosed in a family of Rhodesian Ridgeback dogs. One male and 1 female from the same litter and 1 female from a different litter were evaluated for growth retardation, inability to ambulate, and progressive ataxia. On physical examination, lateral recumbency, severe ataxia, tremors, and diluted coat color were identified. Littermates with nondiluted coat color were neurologically normal. Results of routine laboratory tests, urine metabolic screenings, and karyotype analyses were normal. Histopathologic abnormalities at necropsy included cerebellar Purkinje's cell degeneration, reduced granular cell layer thickness, and uneven distribution of macromelanosomes within hair shafts. Pedigree analysis suggested an autosomal recessive mode of inheritance. This is the first description of a genetic syndrome affecting the central nervous system and associated with coat color dilution in dogs....

Clough, E., Pyle, R. L., Hare, W. C., Kelly, D. F., & Patterson, D. F. (1970). An XXY sex-chromosome constitution in a dog with testicular hypoplasia and congenital heart disease. Cytogenetics, 9(1), 71-7.

Cooper, B. J., Valentine, B. A., Wilson, S., Patterson, D. F., & Concannon, P. W. (1988). Canine muscular dystrophy: confirmation of X-linked inheritance. Journal of Heredity, 79(6), 405-408.

De Reeder, E. G., Girard, N., Poelmann, R. E., Van Munsteren, J. C., Patterson, D. F., & Gittenberger De Groot, A. C. (1988). Hyaluronic acid accumulation and endothelial cell detachment in intimal thickening of the vessel wall. The normal and genetically defective ductus arteriosus. Am J Pathol, 132(3), 574-85.

Desnick, R. J., Patterson, D. F., & Scarpelli, D. G. (1982). Animal models of inherited metabolic diseases. Proceedings of the International Symposium held in Bethesda, Maryland, October 19-20 1981. , 94.

Detweiler, D. K., Luginbuhl, H., Buchanan, J. W., & Patterson, D. F. (1968). The natural history of acquired cardiac disability of the dog. Ann N Y Acad Sci, 147(8), 318-29.

Detweiler, D. K., Patterson, D. F., & Luginbbhl, H. (1972). Observations on naturally occurring myocardial fibrosis and necrosis in dogs. Recent Adv Stud Cardiac Struct Metab, 1, 574-8.

 Detweiler, D. K., Patterson, D. F., Buchanan, J. W., Knight, D. H., & E, J. C. (1979). The cardiovascular system. Canine medicine. Volume II, 4th edition, 813-949.

Eigenmann, J. E., & Patterson, D. F. (1984). Growth hormone deficiency in the mature dog. Journal of the American Animal Hospital Association, 20(5), 741-746.....

Eigenmann, J. E., Amador, A., & Patterson, D. F. (1988). Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs. Acta Endocrinologica, 118(1), 105-108. Plasma insulin-like growth factor I (IGFI) concentrations in dogs of proportionate, chondrodystrophic and giant breeds were evaluated and compared with body size.....

Eigenmann, J. E., Patterson, D. F., Zapf, J., & Froesch, E. R. (1984). Insulin-like growth factor I in the dog: a study in different dog breeds and in dogs with growth hormone elevation. Acta Endocrinologica, 105(3), 294-301.

Fyfe, J. C., Giger, U., Hall, C. A., Jezyk, P. F., Klumpp, S. A., Levine, J. S., & Patterson, D. F. (1991). Inherited selective intestinal cobalamin malabsorption and cobalamin deficiency in dogs. Pediatric Research, 29(1), 24-31. Inherited selective intestinal malabsorption of cobalamin (Cbl) was observed in a family of Giant Schnauzer dogs. Family studies and breeding experiments demonstrated simple autosomal recessive inheritance of this disease.

Fyfe, J. C., Giger, U., Winkle, T. J. v., Haskins, M. E., Steinberg, S. A., Wang, P., Patterson, D. F., & Van Winkle, T. J. (1992). Glycogen storage disease type IV: inherited deficiency of branching enzyme activity in cats. Pediatric Research, 32(6), 719-725. Glycogen storage disease type IV due to branching enzyme deficiency was found in an inbred family of Norwegian forest cats, an uncommon breed of domestic cats. Skeletal muscle, heart and central nervous system degeneration were clinically apparent and histologically evident in affected cats more than 5 months old, but cirrhosis and hepatic failure, hallmarks of the human disorder, were absent. ....

Fyfe, J. C., Jezyk, P. F., Giger, U., & Patterson, D. F. (1989). Inherited selective malabsorption of vitamin B12 in Giant Schnauzers. Journal of the American Animal Hospital Association, 25(5), 533-539. Two related Giant Schnauzers developed chronic inappetance, lethargy, cachexia, and failure to thrive at 12 weeks of age.....

Fyfe, J. C., Kurzhals, R. L., Lassaline, M. E., Henthorn, P. S., Alur, P. R., Wang, P., Wolfe, J. H., Giger, U., Haskins, M. E., Patterson, D. F., Sun, H., Jain, S., & Yuhki, N. (1999). Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII. Genomics, 58(2), 121-8.

Fyfe, J. C., Kurzhals, R. L., Lassaline, M. E., Henthorn, P. S., Alur, P. R. K., Wang, P., Wolfe, J. H., Giger, U., Haskins, M. E., Patterson, D. F., Sun, H., Sanjeev, J., Yuhki, N., Wang, P., Sun, H. C., & Jain, S. (1999). Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII. Genomics San Diego, 58(2), 121-128.

Fyfe, J. C., Winkle, T. J. v., Haskins, M. E., Patterson, D. F., & Van Winkle, T. J. (1994). Animal model of human disease. Glycogen storage disease type IV. Comparative Pathology Bulletin, 26(3), 3,6.

Giger, U., Meyers Wallen, V. N., & Patterson, D. F. (1989). A 6-month-old Doberman pinscher with ambiguous genitalia as a first case of X-chromosomal monosomy in the dog [letter; comment]. J Vet Intern Med, 3(4), 245.

Giger, U., Smith, B. F., Woods, C. B., Patterson, D. F., & Stedman, H. (1992). Inherited phosphofructokinase deficiency in an American Cocker Spaniel. Journal of the American Veterinary Medical Association, 201(10), 1569-1571. A 3-year-old female American Cocker Spaniel with a chronic haemolytic disorder and haemolytic crises was found to have M-type phosphofructokinase deficiency. This inherited erythroenzymopathy and myopathy is commonly diagnosed in English Springer Spaniels, but the family study of this Cocker Spaniel, although supporting an autosomal recessive mode of inheritance, did not reveal any English Springer Spaniel ancestors. Molecular genetic studies did, however, identify the same mutation in this dog as the authors previously reported in the English Springer Spaniel breed, suggesting that this mutation originated prior to the separation of these 2 breeds.

Haskins, M. E., Aguirre, G. D., Jezyk, P. F., & Patterson, D. F. (1980). The pathology of the feline model of mucopolysaccharidosis VI. American Journal of Pathology, 101(3), 657-674.

Haskins, M. E., Aguirre, G. D., Jezyk, P. F., Desnick, R. J., & Patterson, D. F. (1983). The pathology of the feline model of mucopolysaccharidosis I. American Journal of Pathology, 112(1), 27-36.

Haskins, M. E., Aguirre, G. D., Jezyk, P. F., Schuchman, E. H., Desnick, R. J., & Patterson, D. F. (1991). Mucopolysaccharidosis type VII (Sly syndrome). Beta-glucuronidase-deficient mucopolysaccharidosis in the dog. Am J Pathol, 138(6), 1553-5.

Haskins, M. E., Desnick, R. J., DiFerrante, N., Jezyk, P. F., & Patterson, D. F. (1984). Beta-glucuronidase deficiency in a dog: a model of human mucopolysaccharidosis VII. Pediatr Res, 18(10), 980-4. This report describes a third mucopolysaccharidosis in animals: canine mucopolysaccharidosis VII. ....

Haskins, M. E., Jezyk, P. F., Desnick, R. J., McDonough, S. K., & Patterson, D. F. (1979). Alpha-L-iduronidase deficiency in a cat: a model of mucopolysaccharidosis I. Pediatric Research, 13(11), 1294-1297.

Haskins, M. E., Jezyk, P. F., Desnick, R. J., McDonough, S. K., & Patterson, D. F. (1979). Mucopolysaccharidosis in a domestic short-haired cat: a disease distinct from that seen in the Siamese cat. Journal of the American Veterinary Medical Association, 175(4), 384-387.

Haskins, M. E., Jezyk, P. F., Desnick, R. J., McGovern, M. M., Vine, D. T., & Patterson, D. F. (1982). Animal models of mucopolysaccharidosis. Animal models of inherited metabolic diseases, 177-201; Progress in Clinical and Biological Research, Volume 94. Studies on the clinical features, pathology, enzymology and genetics of mucopolysaccharidoses I and VI in cats are reviewed, and a case of mucopolysaccharidosis in a dog is described.

Haskins, M. E., Patterson, D. F., & J, H. (1987). Inherited metabolic diseases. Diseases of the cat: medicine and surgery, 1, 807-819.

Henthorn PS, Liu J, Gidalevich T, Fang J, Casal ML, Patterson DF, Giger U. (2000). Canine cystinuria: polymorphism in the canine SLC3A1 gene and identification of a nonsense mutation in cystinuric Newfoundland dogs. Hum Genet, Oct;107(4):295-303.

Henthorn, P. S., Somberg, R. L., Fimiani, V. M., Puck, J. M., Patterson, D. F., & Felsburg, P. J. (1994). IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease. Genomics, 23(1), 69-74.

Jezyk, P. F., Felsburg, P. J., Haskins, M. E., & Patterson, D. F. (1989). X-linked severe combined immunodeficiency in the dog. Clinical Immunology and Immunopathology, 52(2), 173-189.

Jezyk, P. F., Haskins, M. E., & Patterson, D. F. (1982). Screening for inborn errors of metabolism in dogs and cats. Prog Clin Biol Res, 94, 93-116.

Jezyk, P. F., Haskins, M. E., MacKay Smith, W. E., & Patterson, D. F. (1986). Lethal acrodermatitis in Bull Terriers. Journal of the American Veterinary Medical Association, 188(8), 833-839. A lethal syndrome characterized clinically by retarded growth, progressive acrodermatitis, chronic pyoderma and paronychia, diarrhoea, pneumonia, and abnormal behaviour was observed in 17 related Bull Terrier pups.....

Jezyk, P. F., Haskins, M. E., Patterson, D. F., Mellman, W. J., & Greenstein, M. (1977). Mucopolysaccharidosis in a cat with arylsulfatase B deficiency: a model of Maroteaux-Lamy syndrome. Science, 198(4319), 834-6.

Li, R., Mignot, E., Faraco, J., Kadotani, H., Cantanese, J., Zhao, B., Lin, X., Hinton, L., Ostrander, E. A., Patterson, D. F., & de Jong, P. J. (1999). Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. Genomics, 58(1), 9-17. A large insert canine genomic bacterial artificial chromosome (BAC) library was built from a Doberman pinscher. Approximately 166,000 clones were gridded on nine high-density hybridization filters. Insert analysis of randomly selected clones indicated a mean insert size of 155 kb and predicted 8.1 coverage of the canine genome. Two percent of the clones were nonrecombinant. Chromosomal fluorescence in situ hybridization studies of 60 BAC clones indicated no chimerism. The library was hybridized with dog PCR products representing eight genes (ADA, TNFA, GCA, MYB, HOXA, GUSB, THY1, and TOP1). The resulting positive clones were characterized and shown to be compatible with an eightfold redundant library.

 Marshall, L. S., Oehlert, M. L., Haskins, M. E., Selden, J. R., & Patterson, D. F. (1982). Persistent Mullerian duct syndrome in Miniature Schnauzers. Journal of the American Veterinary Medical Association, 181(8), 798-801.

McAloose, D., Casal, M., Patterson, D. F., & Dambach, D. M. (1998). Polycystic kidney and liver disease in two related West Highland White Terrier litters. Veterinary Pathology, 35(1), 77-81.

Mellersh CS, Hitte C, Richman M, Vignaux F, Priat C, Jouquand S, Werner P, Andre C, DeRose S, Patterson DF, Ostrander EA, Galibert F. (2000). An integrated linkage-radiation hybrid map of the canine genome. Mamm Genome, Feb;11(2):120-30.
Mellersh, C. S., Hitte, C., Richman, M., Vignaux, F., Priat, C., Jouquand, S., Werner, P., Andre, C., DeRose, S., Patterson, D. F., Ostrander, E. A., & Galibert, F. (2000 Feb). An integrated linkage-radiation hybrid map of the canine genome. Mamm Genome, 11(2), 120-30. Purebred dogs are a unique resource for dissecting the molecular basis of simple and complex genetic diseases and traits. As a result of strong selection for physical and behavioral characteristics among the 300 established breeds, modern dogs are characterized by high levels of interbreed variation, complemented by significant intrabreed homogeneity. A high-resolution map of the canine genome is necessary to exploit the mapping power of this unusual resource. We describe here the integration of an expanded canine radiation hybrid map, comprised of 600 markers, with the latest linkage map of 341 markers, to generate a map of 724 markers-the densest map of the canine genome described to date. Through the inclusion of 217 markers on both the linkage and RH maps, the 77 RH groups are reduced to 44 syntenic groups, thus providing comprehensive coverage of most of the canine genome.

Melniczek, J. R., Dambach, D., Prociuk, U., Jezyk, P. F., Henthorn, P. S., Patterson, D. F., & Giger, U. (1999). Sry-negative XX sex reversal in a family of Norwegian Elkhounds. J Vet Intern Med, 13(6), 564-9 .

Meyers Wallen, V. N., & Patterson, D. F. (1988). XX sex reversal in the American cocker spaniel dog: phenotypic expression and inheritance. Human Genetics, 80(1), 23-30.

Meyers Wallen, V. N., & Patterson, D. F. (1989). Sexual differentiation and inherited disorders of sexual development in the dog. Journal of Reproduction and Fertility, Supplement No. 39, 57-64. A review in which consideration is given to abnormalities of (1) chromosomal sex (chromosome number, chimaerism, mosaicism), (2) gonadal sex (XX sex reversal, intersexuality), and (3) phenotypic sex (male and female pseudohermaphroditism, cryptorchidism) in the dog.

Meyers Wallen, V. N., Donahoe, P. K., Manganaro, T., & Patterson, D. F. (1987). Mullerian inhibiting substance in sex-reversed dogs. Biology of Reproduction, 37(4), 1015-1022.

Meyers Wallen, V. N., Wilson, J. D., Griffin, J. E., Fisher, S., Moorhead, P. H., Goldschmidt, M. H., Haskins, M. E., & Patterson, D. F. (1989). Testicular feminization in a cat [see comments]. J Am Vet Med Assoc, 195(5), 631-4.

Meyers, V. N., Jezyk, P. F., Aguirre, G. D., & Patterson, D. F. (1983). Short-limbed dwarfism and ocular defects in the Samoyed dog. Journal of the American Veterinary Medical Association, 183(9), 975-979.

Mierop, L. H. S. V., Patterson, D. F., Schnarr, W. R., & Van Mierop, L. H. S. (1977). Hereditary conotruncal septal defects in Keeshond dogs: embryologic studies. American Journal of Cardiology, 40(6), 936-950.

Mierop, L. H. S. V., Patterson, D. F., Schnarr, W. R., & Van Mierop, L. H. S. (1978). Pathogenesis of persistent truncus arteriosus in light of observations made in a dog embryo with the anomaly. American Journal of Cardiology, 41(4), 755-762.

Minor, R. R., Lein, D. H., Patterson, D. F., Krook, L., Porter, T. G., & Kane, A. C. (1983). Defects in collagen fibrillogenesis causing hyperextensible, fragile skin in dogs. Journal of the American Veterinary Medical Association, 182(2), 142-148.

Minor, R. R., Wootton, J. A., Prockop, D. J., & Patterson, D. F. (1987). Genetic diseases of connective tissues in animals. Curr Probl Dermatol, 17, 199-215.

O' Brien, S. J., Haskins, M. E., Winkler, C. A., Nash, W. G., & Patterson, D. F. (1986). Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group. Journal of Heredity, 77(6), 374-378. Siamese cats are homozygous for the recessive cs allele of the colour (albino) locus. The c locus was shown, by backcross analysis, to be linked to the beta-haemoglobin (HBB) locus in the cat at a distance of approx. 8 centiMorgans. The HBB locus and, by inference, the c locus were assigned to feline chromosome D1, by analysis of genomic DNAs from a panel of rodent X cat somatic cell hybrids with a molecular clone of the human beta-globin locus. Evolutionary conservation of the syntenic homology of feline chromosome D1 and human chromosome 11 is extensive. Comparison of high resolution G-trypsin-banded preparations of the 2 chromosomes permitted cytological alignment of the long arm of the conserved chromosomes, providing that a min. of 1 paracentric inversion is hypothesised.

Ostrander, E. A., Galibert, F., & Patterson, D. F. (2000). Canine genetics comes of age. Trends Genet, 16(3), 117-24. The dog, as human's favored companion, is unique among animal species in providing new insights into human genetic disease. In this review, we will discuss both the breed and the population structure of dogs and why that makes canines amenable to genetic studies. We will review the current state of the map and discuss the particular disease states in which canines stand to make the greatest contribution to medical genetics.

Patterson DF. (2000). Companion animal medicine in the age of medical genetics. J Vet Intern Med, Jan-Feb;14(1):1-9.

Patterson, D. F. (1974). Comparative medical genetics: studies in domestic animals. Birth Defects Orig Artic Ser, 10(10), 263-77.

Patterson, D. F. (1974). Medical genetics. Journal of the American Veterinary Medical Association, 165(No.8), 728.

Patterson, D. F. (1974). Pathologic and genetic studies of congenital heart disease in the dog. Adv Cardiol, 13, 210-49.

Patterson, D. F. (1974). Pathologic and genetic studies of congenital heart disease in the dog. Advances in Cardiology, 13(210-249.

Patterson, D. F. (1975). Diseases due to single mutant genes. Journal of the American Animal Hospital Association, 11(3), 327-341. Following short descriptions of the transcription and translation of DNA, genetic regulation and Mendelian inheritance, inherited blood diseases and diseases and abnormalities due to the pleiotropic effect of single genes are briefly reviewed, and the elimination of genetic diseases is discussed.

Patterson, D. F. (1977). A catalog of genetic disorders of the dog. Current veterinary therapy. VI. Small animal practice. Genetic disorders of the blood, bones and joints, endocrine organs, metabolism, cardiovascular and lymphatic systems, digestive system, ear, eye, neuromuscular system, skin and urinary system are listed in separate tables, with details of the breeds affected, the mode of inheritance and selected references. Details of chromosome abnormalities and susceptibility to diseases are also listed in this fashion.

Patterson, D. F. (1979). Genetics in small animal medicine. New findings on hereditary diseases of metabolism and congenital abnormalities in dogs and cats. Praktische Tierarzt, 60(12), 1061...1082.

 Patterson, D. F. (1980). Genetics in small animal medicine. Recent findings on hereditary metabolic disorders and congenital abnormalities in dogs and cats. Kleintierpraxis, 25(2), 104, 106.

 Patterson, D. F. (1989). Hereditary congenital heart defects in dogs. Journal of Small Animal Practice, 30(3), 153...165.

Patterson, D. F. (1993). Understanding and controlling inherited diseases in dogs and cats. Tijdschrift voor Diergeneeskunde, 118(Sup 1), 23s-27s.

Patterson, D. F. (2000). Companion animal medicine in the age of medical genetics. J Vet Intern Med, 14(1), 1-9.

Patterson, D. F., & Minor, R. R. (1977). Hereditary fragility and hyperextensibility of the skin of cats. A defect in collagen fibrillogenesis. Laboratory Investigation, 37(2), 170-179.

Patterson, D. F., Aguirre, G. A., Fyfe, J. C., Giger, U., Green, P. L., Haskens, M. E., Jezyk, P. F., & Meyers Wallen, V. N. (1989). Is this a genetic disease? Journal of Small Animal Practice, 30(3), 127-139. This paper begins with a brief summary of knowledge concerning the frequency and types of genetic diseases in small domestic animals, particularly the dog. The major question considered is, 'How does one recognise that a given disease has an important genetic component in its cause?' Six lines of evidence leading to that conclusion are discussed and exemplified by a variety of known and suspected genetic diseases in the dog and cat.

Patterson, D. F., Haskins, M. E., & Jezyk, P. F. (1982). Models of human genetic disease in domestic animals. Adv Hum Genet, 12, 263-339.

Patterson, D. F., Haskins, M. E., & Schnarr, W. R. (1981). Hereditary dysplasia of the pulmonary valve in beagle dogs. Pathologic and genetic studies. Am J Cardiol, 47(3), 631-41.

Patterson, D. F., Haskins, M. E., Jezyk, P. F., Giger, U., Meyers Wallen, V. N., Aguirre, G., Fyfe, J. C., & Wolfe, J. H. (1988). Research on genetic diseases; reciprocal benefits to animals and man. Journal of the American Veterinary Medical Association, 193(9), 1131-1144. A review of similarities in genetic diseases between cats and dogs and humans, including consideration of the beta-globin and albino loci in cats and humans, cardiovascular studies in dogs, and inborn errors of metabolism in cats, dogs and humans. Gene therapy in domestic animals is discussed.

Patterson, D. F., Pexieder, T., Schnarr, W. R., Navratil, T., & Alaili, R. (1993). A single major-gene defect underlying cardiac conotruncal malformations interferes with myocardial growth during embryonic development: studies in the CTD line of keeshond dogs. Am J Hum Genet, 52(2), 388-97.

Patterson, D. F., Pyle, R. L., Mierop, L. v., Melbin, J., & Olson, M. (1974). Hereditary defects of the conotruncal septum in Keeshond dogs: pathologic and genetic studies. American Journal of Cardiology, 34(No.2), 187-205.

Pyle, R. L., Patterson, D. F., Hare, W. C. D., Kelly, D. F., & Digiulio, T. (1971). XXY sex chromosome constitution in a Himalayan cat with tortoise-shell points. Journal of Heredity, 62(No.4), 220-222.

Ray, J., Bouvet, A., DeSanto, C., Fyfe, J. C., Xu, D., Wolfe, J. H., Aguirre, G. D., Patterson, D. F., Haskins, M. E., Henthorn, P. S., & Xu, D. B. (1998). Cloning of the canine beta-glucuronidase cDNA, mutation identification in canine MPS VII, and retroviral vector-mediated correction of MPS VII cells. Genomics San Diego, 48(2), 248-253.

Rhodes, T. H., Vite, C. H., Giger, U., Patterson, D. F., Fahlke, C., & George, A. L., Jr. (1999). A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog. FEBS Lett, 456(1), 54-8.

Riser, W. H., Haskins, M. E., Jezyk, P. F., & Patterson, D. F. (1980). Pseudoachondroplastic dysplasia in miniature poodles: clinical, radiologic, and pathologic features. Journal of the American Veterinary Medical Association, 176(4), 335-341.

Schiffer, S. P., Prochazka, M., Jezyk, P. F., Roderick, T. H., Yudkoff, M., & Patterson, D. F. (1989). Organic aciduria and butyryl CoA dehydrogenase deficiency in BALB/cByJ mice. Biochem Genet, 27(1-2), 47-58.

Selden, J. R., Moorhead, P. S., Koo, G. C., Wachtel, S. S., Haskins, M. E., & Patterson, D. F. (1984). Inherited XX sex reversal in the cocker spaniel dog. Human Genetics, 67(1), 62-69.

Selden, J. R., Moorhead, P. S., Oehlert, M. L., & Patterson, D. F. (1975). The Giemsa banding pattern of the canine karyotype. Cytogenetics and Cell Genetics, 15(6), 380-387.

 Selden, J. R., Moorhead, P. S., Oehlert, M. L., & Patterson, D. F. (1976). The Giemsa banding pattern of the canine karyotype. Mammalian Chromosomes Newsletter, 17(1-2), 60.

Selden, J. R., Wachtel, S. S., Koo, G. C., Haskins, M. E., & Patterson, D. F. (1978). Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog. Science, USA, 201(4356), 644-646.

Smith, B. F., Henthorn, P. S., Rajpurohit, Y., Stedman, H., Wolfe, J. H., Patterson, D. F., & Giger, U. (1996). A cDNA encoding canine muscle-type phosphofructokinase. Gene, 168(2), 275-6.

Smith, B. F., Stedman, H., Rajpurohit, Y., Henthorn, P. S., Wolfe, J. H., Patterson, D. F., & Giger, U. (1996). Molecular basis of canine muscle type phosphofructokinase deficiency. Journal of Biological Chemistry, 271(33), 20070-20074.

Somberg, R. L., Pullen, R. P., Casal, M. L., Patterson, D. F., Felsburg, P. J., & Henthorn, P. S. (1995). A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease. Veterinary Immunology and Immunopathology, 47(3-4), 203-213.

Stramm, L. E., Wolfe, J. H., Schuchman, E. H., Haskins, M. E., Patterson, D. F., & Aguirre, G. D. (1990). Beta-glucuronidase mediated pathway essential for retinal pigment epithelial degradation of glycosaminoglycans. Disease expression and in vitro disease correction using retroviral mediated cDNA transfer. Exp Eye Res, 50(5), 521-32.

Sun, H., Yang, M., Haskins, M. E., Patterson, D. F., & Wolfe, J. H. (1999). Retrovirus vector-mediated correction and cross-correction of lysosomal alpha-mannosidase deficiency in human and feline fibroblasts. Hum Gene Ther, 10(8), 1311-9.

Wenger, D. A., Victoria, T., Rafi, M. A., Luzi, P., Vanier, M. T., Vite, C., Patterson, D. F., & Haskins, M. H. (1999). Globoid cell leukodystrophy in Cairn and West Highland White terriers. International workshop on canine genetics; the map, the genes, the diseases, Cornell University, New York, USA, 12 13 July 1997, 90(1), 138-142.

Werner P, Raducha MG, Shin D, Ostrander EA, Kirkness E, Patterson DF, Henthorn PS. (2004). Assignment of 10 canine genes to the canine linkage and comparative maps. Anim Genet, Jun;35(3):249-51.

Werner, P., Mellersh, C. S., Raducha, M. G., DeRose, S., Acland, G. M., Prociuk, U., Wiegand, N., Aguirre, G. D., Henthorn, P. S., Patterson, D. F., & Ostrander, E. A. (1999). Anchoring of canine linkage groups with chromosome-specific markers. Mammalian Genome, 10(8), 814-823.

Werner, P., Raducha, M. G., Prociuk, U., Budarf, M., Henthorn, P. S., & Patterson, D. F. (1999). Comparative mapping of the DiGeorge region in the dog and exclusion of linkage to inherited canine conotruncal heart defects. Journal of Heredity, 90(4), 494-498.

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